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Bethyl Laboratories
ABCC2 Polyclonal Antibody
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FIGURE: 1 / 1
ABCC2 Antibody (A304-420A) in IP
Detection of human ABCC2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) prepared using NETN buffer from Hep-G2 cells. Antibodies: Affinity purified rabbit anti-ABCC2 antibody (Product # A304-420A) (lot 1) used for IP at 6 µg per reaction. ABCC2 was also immunoprecipitated by rabbit anti-ABCC2 antibody BL15953. For blotting immunoprecipitated ABCC2, A304-420A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A304-420A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 825 to 875 of human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Human MRP2; KIAA1010; Multidrug resistance-associated protein 2
Gene Aliases: ABC30; ABCC2; CMOAT; CMOAT1; CMRP; DJS; MRP2
UniProt ID: (Human) Q92887
Entrez Gene ID: (Human) 1244
nucleotide binding
protein binding
ATP binding
organic anion transmembrane transporter activity
xenobiotic-transporting ATPase activity
bilirubin transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
ATPase activity
transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
ABC-type transporter activity
xenobiotic metabolic process
drug transmembrane transport
lipid transport
negative regulation of gene expression
bile acid and bile salt transport
bilirubin transport
heme catabolic process
drug export
carboxylic acid transport
transmembrane transport
transepithelial transport
leukotriene transport
anion transmembrane transport
transport across blood-brain barrier
drug transport across blood-brain barrier
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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