Proteintech

ABCC6 Polyclonal Antibody

2 Published Figures

8 References

View all (13) MRP6 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (3)
Published Figures (2)

ABCC6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

ABCC6 Antibody (27848-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse liver tissue slide using 27848-1-AP (ABCC6 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

27848-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ABCC6 Fusion Protein Ag18640 (1219-1503 aa encoded by BC131732)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

27848-1-AP detects two isoforms of ABCC6 protein around 165 kDa and 96 kDa in SDS-PAGE.

Immunogen sequence: VVRNWTDLE NSIVSVERMQ DYAWTPKEAP WRLPTCAAQP PWPQGGQIEF RDFGLRYRPE LPLAVQGVSF KIHAGEKVGI VGRTGAGKSS LASGLLRLQE AAEGGIWIDG VPIAHVGLHT LRSRISIIPQ DPILFPGSLR MNLDLLQEHS DEAIWAALET VQLKALVASL PGQLQYKCAD RGEDLSVGQK QLLCLARALL RKTQILILDE ATAAVDPGTE LQMQAMLGSW FAQCTVLLIA HRLRSVMDCA RVLVMDKGQV AESGSPAQLL AQKGLFYRLA QESGLV (1219-1503 aa encoded by BC131732)

Target Information

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ABCC6 Knockdown Fuels Cell Proliferation by Regulating PPARα in Hepatocellular Carcinoma.

Frontiers in oncology

Zhao Z,Zhao Z,Wang J,Zhang H,Xi Z,Xia Q

Published figure using ABCC6 polyclonal antibody (Product # 27848-1-AP) in Western Blot

Wed Mar 16 00:00:00 UTC 2022

ABCC6 Knockdown Fuels Cell Proliferation by Regulating PPARα in Hepatocellular Carcinoma.

Frontiers in oncology

Zhao Z,Zhao Z,Wang J,Zhang H,Xi Z,Xia Q

Published figure using ABCC6 polyclonal antibody (Product # 27848-1-AP) in Western Blot

Wed Mar 16 00:00:00 UTC 2022

CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease.

Cells

Liu Y,Huang Y,Zhang X,Ma X,He X,Gan C,Zou X,Wang S,Shu K,Lei T,Zhang H

Sat Nov 26 00:00:00 UTC 2022

CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease.

Cells

Liu Y,Huang Y,Zhang X,Ma X,He X,Gan C,Zou X,Wang S,Shu K,Lei T,Zhang H

Sat Nov 26 00:00:00 UTC 2022

CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease.

Cells

Liu Y,Huang Y,Zhang X,Ma X,He X,Gan C,Zou X,Wang S,Shu K,Lei T,Zhang H

Sat Nov 26 00:00:00 UTC 2022

A Novel Idiopathic Atrial Calcification: Pathologic Manifestations and Potential Mechanism.

Frontiers in cardiovascular medicine

Li B,Liu Q,Chen X,Chen T,Dang W,Zhao J,Cui G,Chen K,Wu Y

Fri Apr 08 00:00:00 UTC 2022

Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma.

Frontiers in genetics

Zhou X,Huang JM,Li TM,Liu JQ,Wei ZL,Lan CL,Zhu GZ,Liao XW,Ye XP,Peng T

Tue Mar 29 00:00:00 UTC 2022

Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells.

Oncology letters

Wang H,Chi CH,Zhang Y,Shi B,Jia R,Wang BJ

Mon Jul 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Anthracycline resistance-associated protein; ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, sub-family C, member 6; MOAT-E; Multi-specific organic anion transporter E; Multidrug resistance-associated protein 6; multidrug resistance-associated protein-6

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Gene Aliases: ABC34; Abcc1b; ABCC6; ARA; DCC; dyscalc; Dyscalc1; EST349056; GACI2; MLP1; MOAT-E; MOATE; MRP6; PXE; PXE1; URG7

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UniProt ID: (Human) O95255, (Mouse) Q9R1S7

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Entrez Gene ID: (Human) 368, (Mouse) 27421

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Function(s)

transporter activity ATP binding ATPase activity, coupled to transmembrane movement of substances anion transmembrane-transporting ATPase activity nucleotide binding ATPase activity ATP-binding cassette (ABC) transporter

Process(es)

transport visual perception response to drug transmembrane transport anion transmembrane transport metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ABCC6 Polyclonal Antibody

ABCC6 Antibody (27848-1-AP) in IHC (P)

Product Details

27848-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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