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Invitrogen
ABCC6 Polyclonal Antibody
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FIGURE: 1 / 3
ABCC6 Antibody (PA5-103933) in IHC (P)
Immunohistochemistry analysis of ABCC6 in mouse kidney tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ABCC6 polyclonal antibody (Product # PA5-103933) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103933
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ABCC6(Accession O95255), corresponding to amino acid residues L316-F366.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MRP6.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Anthracycline resistance-associated protein; ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, sub-family C, member 6; liver multidrug resistance-associated protein 6; MLP-1; MOAT-E; MRP-like protein 1; Multi-specific organic anion transporter E; Multidrug resistance-associated protein 6; multidrug resistance-associated protein-6; similar to multidrug resistance protein MRP1; unnamed protein product
Gene Aliases: ABC34; Abcc1b; ABCC6; ARA; DCC; dyscalc; Dyscalc1; EST349056; GACI2; MLP1; MOAT-E; MOATE; MRP6; PXE; PXE1; URG7
UniProt ID: (Human) O95255, (Mouse) Q9R1S7, (Rat) O88269
Entrez Gene ID: (Human) 368, (Mouse) 27421, (Rat) 81642
nucleotide binding
ATP binding
glutathione S-conjugate-exporting ATPase activity
ATPase activity
transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
anion transmembrane-transporting ATPase activity
ABC-type transporter activity
ATP-binding cassette (ABC) transporter
visual perception
response to xenobiotic stimulus
gene expression
ATP transport
inorganic diphosphate transport
cellular phosphate ion homeostasis
response to magnesium ion
ATP metabolic process
carboxylic acid transport
phosphate ion homeostasis
calcium ion homeostasis
transmembrane transport
leukotriene transport
anion transmembrane transport
inhibition of non-skeletal tissue mineralization
response to sodium phosphate
transport
metabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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