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ABCC8 Polyclonal Antibody
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Product Details
OSA00224W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 600-700 of human ABCC8 conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: ABCC8.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AM60008PU-N; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; PH SUR1; sulfonylurea receptor (hyperinsulinemia); Sulfonylurea receptor 1; unnamed protein product
Gene Aliases: ABC36; ABCC8; HHF1; HI; HRINS; MODY12; MRP8; PHHI; PNDM3; SUR; SUR1; SUR1delta2; TNDM2
UniProt ID: (Human) Q09428
Entrez Gene ID: (Human) 6833
action potential
cellular glucose homeostasis
potassium ion transport
female pregnancy
memory
visual learning
response to pH
response to xenobiotic stimulus
response to zinc ion
negative regulation of low-density lipoprotein particle clearance
negative regulation of angiogenesis
cellular response to nutrient levels
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
response to insulin
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of potassium ion transport
negative regulation of insulin secretion
negative regulation of neurogenesis
neuromuscular process
transmembrane transport
negative regulation of glial cell proliferation
glutamate secretion, neurotransmission
negative regulation of neuroblast migration
potassium ion transmembrane transport
inorganic cation transmembrane transport
positive regulation of uterine smooth muscle relaxation
positive regulation of occluding junction disassembly
negative regulation of blood-brain barrier permeability
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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