Peptide sequence: AVVTEGGENF SVGQRQLFCL ARAFVRKSSI LIMDEATASI DMATENILQK
Sequence homology: Cow: 100%; Dog: 100%; Goat: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
ABCC9 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. No disease has been associated with this gene thus far. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion.
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Protein Aliases: ABC37; ATFB12; ATP-binding cassette; ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; cardiac ventricle sulfonyl urea receptor; CMD1O; FLJ36852; sub-family C (CFTR/MRP) member 9; Sulfonylurea receptor 2; sulfonylurea receptor subunit 2; sulfonylurea-binding protein 2; sulphonylurea receptor 2; sulphonylurea receptor 2A; sulphonylurea receptor 2B; SUR2; SUR2A; SUR2B
Gene Aliases: ABC37; ABCC9; AI414027; AI449286; ATFB12; CANTU; CMD1O; si:dkey-183c2.3; SUR2; SUR2A; SUR2B