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Invitrogen
ABCC9 Polyclonal Antibody
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FIGURE: 1 / 3
ABCC9 Antibody (PA5-42398) in WB
Western blot analysis of mouse brain cell lysate using an anti-ABCC9 polyclonal antibody (Product # PA5-42398). Primary Antibody Dilution: 1:1000; Secondary Antibody: Anti-rabbit HRP; Secondary Antibody Dilution: 1:2000. LANE 1) 10µg SUR1 KO mouse ventricle lysate; LANE 2) 10µg WT mouse ventricle lysate; LANE 3) 0.1µg SUR1 overexpressing mouse ventricle lysate; LANE 4) 10µg cannine ventricle lysate.
Product Details
PA5-42398
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human ABCC9
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: AVVTEGGENF SVGQRQLFCL ARAFVRKSSI LIMDEATASI DMATENILQK
Sequence homology: Cow: 100%; Dog: 100%; Goat: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; FLJ36852; Sulfonylurea receptor 2; sulfonylurea-binding protein 2
Gene Aliases: ABC37; ABCC9; AI414027; AI449286; ATFB12; CANTU; CMD1O; SUR2; SUR2A; SUR2B
UniProt ID: (Human) O60706, (Mouse) P70170
Entrez Gene ID: (Human) 10060, (Mouse) 20928
transporter activity
potassium channel activity
ATP binding
sulfonylurea receptor activity
potassium channel regulator activity
anion transmembrane-transporting ATPase activity
ion channel binding
nucleotide binding
drug binding
ATPase activity
syntaxin binding
ATPase activity, coupled to transmembrane movement of substances
identical protein binding
ATP-binding cassette (ABC) transporter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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