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Immunofluorescent analysis of ABCE1 showing staining in the cytoplasm of HeLa cells. HeLa cells were fixed in 2% paraformaldehyde/culture medium at 37°C for 30 min and stained using an ABCE1 polyclonal antibody (Product # PA5-30993) diluted at 1:500. Blue: Hoechst 33342 staining.
|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 40 and 254 of Human ABCE1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30993 targets ABCE1 in immunohistochemistry, Western blot, immunofluorescence, and immunocytochemistry applications and shows reactivity with Human samples.
The PA5-30993 immunogen is recombinant fragment corresponding to a region within amino acids 40 and 254 of Human ABCE1.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
2'-5'-oligoadenylate-binding protein; 5'-oligoisoadenylate synthetase-dependent) inhibitor; ABC38; ATP-binding cassette, sub-family E (OABP), member 1; huHP68; OABP; ribonuclease 4 inhibitor; ribonuclease L (2'; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; RLI; RNase L inhibitor; RNase L inhibitor 1; RNASEL1; RNASELI; RNS4I
ABC38; ABCE1; OABP; OK/SW-cl.40; RLI; RLI1; RNASEL1; RNASELI; RNS4I