PA5-30993 targets ABCE1 in immunohistochemistry, Western blot, immunofluorescence, and immunocytochemistry applications and shows reactivity with Human samples.
The PA5-30993 immunogen is recombinant fragment corresponding to a region within amino acids 40 and 254 of Human ABCE1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2'-5'-oligoadenylate-binding protein; 5'-oligoisoadenylate synthetase-dependent) inhibitor; ABC38; ATP-binding cassette sub-family E member 1; ATP-binding cassette, sub-family E (OABP), member 1; HuHP68; OABP; Ribonuclease 4 inhibitor; ribonuclease L (2'; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; RLI; RNase L inhibitor; RNase L inhibitor 1; RNASEL1; RNASELI; RNS4I
Gene Aliases: ABC38; ABCE1; OABP; OK/SW-cl.40; RLI; RLI1; RNASEL1; RNASELI; RNS4I
UniProt ID: (Human) P61221
Entrez Gene ID: (Human) 6059