Human Bcl-XL shares 97.9% amino acid (aa) sequence identity with both mouse and rat Bcl-XL.
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
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Protein Aliases: 2'-5'-oligoadenylate-binding protein; ABCE1; ATP-binding cassette sub-family E member 1; ATP-binding cassette, sub-family E (OABP), member 1; ATP-binding cassette, subfamily E, member 1; HuHP68; OK/SW-cl.40; Ribonuclease 4 inhibitor; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) inhibitor; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; RLI; RNase L inhibitor; RNase L inhibitor 1; RNASEL1; RNASELI; RNS4I; RNS4l (Eye)
Gene Aliases: ABC38; ABCE1; C79080; OABP; OK/SW-cl.40; RLI; RLI1; RNASEL1; RNASELI; RNS41; RNS4I