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ABCG1 Polyclonal Antibody
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FIGURE: 1 / 4
ABCG1 Antibody (BS-1231R) in IHC (P)
Paraformaldehyde-fixed, paraffin-embedded Mouse Brain tissue; Antigen retrieval by boiling in sodium citrate buffer (0.01M, pH6) for 15 minutes; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 20 minutes; Antibody incubation with ABCG1 Polyclonal Antibody, Unconjugated (bs-1231R) at 1:400 overnight at 4°C, followed by incubation with a conjugated second... View More
Product Details
BS-1231R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ABCG1, amino acids 561-678.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter 8; ABCG1p; ATP-binding cassette 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette transporter, member 1 of subfamily G; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette, subfamily G, member 1; homolog of Drosophila white; MGC34313; unnamed protein product; white; White protein homolog; white protein homolog (ATP-binding cassette transporter 8)
Gene Aliases: ABC8; ABCG1; AW413978; White; WHITE1; WHT1
UniProt ID: (Human) P45844, (Mouse) Q64343
Entrez Gene ID: (Human) 9619, (Rat) 85264, (Mouse) 11307
nucleotide binding
protein binding
ATP binding
phospholipid binding
cholesterol binding
ATPase activity
toxin transporter activity
sterol-transporting ATPase activity
protein homodimerization activity
ADP binding
protein heterodimerization activity
protein dimerization activity
phosphatidylcholine-translocating ATPase activity
intermembrane cholesterol transfer activity
floppase activity
ABC-type transporter activity
phospholipid transporter activity
cholesterol transporter activity
glycoprotein transporter activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
lipid transport
cholesterol metabolic process
negative regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
negative regulation of lipid storage
cholesterol transport
intracellular cholesterol transport
cholesterol efflux
phospholipid efflux
response to lipid
lipid translocation
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
glycoprotein transport
cholesterol homeostasis
amyloid precursor protein catabolic process
reverse cholesterol transport
positive regulation of cholesterol biosynthetic process
positive regulation of protein secretion
transmembrane transport
phospholipid homeostasis
cellular response to high density lipoprotein particle stimulus
regulation of cholesterol metabolic process
positive regulation of beta-amyloid formation
drug transmembrane export
regulation of transcription, DNA-templated
response to organic substance
regulation of cholesterol esterification
response to high density lipoprotein particle
toxin transport
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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