|Tested species reactivity||Human|
|Host / Isotype||Chicken / IgY|
|Immunogen||Purified recombinant ABCG1 corresponding to the chromosome 21 gene (Human).|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-9535 detects ABCG1 in human samples.
PA1-9535 has been successfully used in Western blot procedures. By Western blot, PA1-9535 detects a 53 kDa protein representing ABCG1.
PA1-9535 immunogen is a purified recombinant ABCG1 corresponding to the chromosome 21 gene (Human).
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.