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Invitrogen
ABCG1 Polyclonal Antibody
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FIGURE: 1 / 1
ABCG1 Antibody (PA5-95071) in WB
Western blot analysis of ABCG1 in Lane 1: U87 whole cell lysate (40 µg), Lane 2: SMMC whole cell lysate (40 µg), Lane 3: HeLa whole cell lysate (40 µg), Lane 4: COLO320 whole cell lysate (40 µg), Lane 5: MCF-7 whole cell lysate (40 µg). Samples were incubated with ABCG1 polyclonal antibody (Product # PA5-95071).
Product Details
PA5-95071
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human ABCG1 (627-647aa ETCHFQKSEAILRELDVENAK).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: U87 whole cell, SMMC whole cell, HELA whole cell, COLO320 whole cell, MCF-7 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter 8; ATP-binding cassette 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette, subfamily G, member 1; homolog of Drosophila white; MGC34313; White protein homolog; white protein homolog (ATP-binding cassette transporter 8)
Gene Aliases: ABC8; ABCG1; AW413978; White; WHITE1; WHT1
UniProt ID: (Human) P45844, (Mouse) Q64343
Entrez Gene ID: (Human) 9619, (Rat) 85264, (Mouse) 11307
ATP binding
phospholipid binding
phospholipid transporter activity
cholesterol binding
cholesterol transporter activity
toxin transporter activity
sterol-transporting ATPase activity
glycoprotein transporter activity
protein homodimerization activity
ADP binding
protein heterodimerization activity
protein dimerization activity
nucleotide binding
ATPase activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
regulation of transcription, DNA-templated
cholesterol metabolic process
detection of hormone stimulus
response to organic substance
negative regulation of macrophage derived foam cell differentiation
regulation of cholesterol esterification
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
intracellular cholesterol transport
cholesterol efflux
phospholipid efflux
response to lipid
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
glycoprotein transport
lipoprotein metabolic process
cholesterol homeostasis
amyloid precursor protein catabolic process
reverse cholesterol transport
positive regulation of cholesterol biosynthetic process
transmembrane transport
phospholipid homeostasis
response to high density lipoprotein particle
toxin transport
negative regulation of lipid storage
cholesterol transport
transport
lipid transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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