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Fabgennix
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The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
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Protein Aliases: Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl 1 antib; ABL kinase domain; abl protein; ABL protooncogene 1 nonreceptor tyrosine kinase; ABL1; ABL2; ABLL; ARG; B30; BCR-ABL1 p190; BCR/ABL e8a2 fusion; BCR/ABL1 e1a2 fusion protein; BCR/ABL1 fusion; bcr/c-abl oncogene protein; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; chimeric BCR::ABL1 protein; non-receptor tyrosine kinase; p150; p190; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; tyrosine kinase protein; Tyrosine-protein kinase ABL1; unnamed protein product; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1
Gene Aliases: ABL; ABL1; AI325092; BCR-ABL; bcr/abl; c-ABL; c-ABL1; CHDSKM; E430008G22Rik; JTK7; p150; v-abl
UniProt ID: (Human) P00519, (Mouse) P00520
Entrez Gene ID: (Human) 25, (Rat) 311860, (Mouse) 11350
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