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Histo-blood group ABO system transferase (NAGAT) is a member of the glycosyltransferase 6 family of proteins and the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B and H; the NAGAT protein functions as the basis of this group. A, B and AB individuals express a glycosyltransferase activity converting the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), while O individuals do not express this glycosyltransferase activity. The B phenotype of NAGAT differs from the A form by a few residue substitutions, whereas the O form is a result of a single base frame-shift deletion in the N-terminal extremity of the gene. The NAGAT protein localizes to the Golgi apparatus and its conserved DXD motif functions in cofactor binding.
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Protein Aliases: A transferase; A1-specific alpha 1-3-N-acetylgalactosaminyltransferase; ABO A3 transferase; ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO glycosyltransferase; ABO weak transfer; B (A) alpha 1; B blood group galactosyltransferase; B transferase; B(A) alpha-1,3-galactosyltransferase; BGAT; Blood group A glycosyltransferase 2; Cis-AB transferase; Cis-AB transferase 2; fucosylglycoprotein; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; glycosyltransferase A; glycosyltransferase B; Histo-blood group A transferase; histo-blood group A2 transferase; Histo-blood group ABO system transferase; Histo-blood group ABO system transferase 2; Histo-blood group B transferase; NAGAT; NAGAT 2; Putative blood group A transferase T2; Transferase; transferase A; transferase B, alpha 1-3-galactosyltransferase)
Gene Aliases: A3GALNT; A3GALT1; ABO; Abo2; GTB; NAGAT
Molecular Function: glycosyltransferase