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Invitrogen
ABO Polyclonal Antibody
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Product Details
PA5-112347
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Histo-blood group ABO system transferase protein (235-354AA)
Conjugate
Form
Liquid
Concentration
3.5 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Histo-blood group ABO system transferase (NAGAT) is a member of the glycosyltransferase 6 family of proteins and the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B and H; the NAGAT protein functions as the basis of this group. A, B and AB individuals express a glycosyltransferase activity converting the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), while O individuals do not express this glycosyltransferase activity. The B phenotype of NAGAT differs from the A form by a few residue substitutions, whereas the O form is a result of a single base frame-shift deletion in the N-terminal extremity of the gene. The NAGAT protein localizes to the Golgi apparatus and its conserved DXD motif functions in cofactor binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A transferase; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase); alpha 1-3-N-acetylgalactosaminyltransferase; Any polymorphism or mutation that changes the activity or specificity of the encoded enzyme may therefore alter the ABO phenotype.; B (A) alpha 1; B transferase; B(A) alpha-1,3-galactosyltransferase; Bel; BGAT; Cis-AB transferase; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Histo-blood group A transferase; histo-blood group A transferase (UDP-GalNAc); histo-blood group A2 transferase; Histo-blood group ABO system transferase; Histo-blood group B transferase; NAGAT; transferase A; A glycosyltransferase; transferase B; Unknown; unnamed protein product
Gene Aliases: A3GALNT; A3GALT1; ABO; GTB; NAGAT
UniProt ID: (Human) P16442, (Mouse) P38649
Entrez Gene ID: (Human) 28, (Mouse) 80908
nucleotide binding
antigen binding
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
fucosylgalactoside 3-alpha-galactosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
manganese ion binding
metal ion binding
alpha-1,3-galactosyltransferase activity
glycosyltransferase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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