This antibody detects endogenous protein at a molecular weight of 41 kDa.
Purity is >95% by SDS-PAGE.
Histo-blood group ABO system transferase (NAGAT) is a member of the glycosyltransferase 6 family of proteins and the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B and H; the NAGAT protein functions as the basis of this group. A, B and AB individuals express a glycosyltransferase activity converting the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), while O individuals do not express this glycosyltransferase activity. The B phenotype of NAGAT differs from the A form by a few residue substitutions, whereas the O form is a result of a single base frame-shift deletion in the N-terminal extremity of the gene. The NAGAT protein localizes to the Golgi apparatus and its conserved DXD motif functions in cofactor binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A transferase; A1-specific alpha 1-3-N-acetylgalactosaminyltransferase; ABO A3 transferase; ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO glycosyltransferase; ABO weak transfer; B (A) alpha 1; B blood group galactosyltransferase; B transferase; B(A) alpha-1,3-galactosyltransferase; BGAT; Blood group A glycosyltransferase 2; Cis-AB transferase; Cis-AB transferase 2; fucosylglycoprotein; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; glycosyltransferase A; glycosyltransferase B; Histo-blood group A transferase; histo-blood group A2 transferase; Histo-blood group ABO system transferase; Histo-blood group ABO system transferase 2; Histo-blood group B transferase; NAGAT; NAGAT 2; Putative blood group A transferase T2; Transferase; transferase A; transferase B, alpha 1-3-galactosyltransferase)
Gene Aliases: A3GALNT; A3GALT1; ABO; Abo2; GTB; NAGAT
Molecular Function: glycosyltransferase