Immunogen sequence: LYSNFSYGTDE YDGEGNEEQK GPPEGSETMP YIDESPTMSP QLSARSQGGG DGVSPTPPEG LAPGVEAGK
Highest antigen sequence identity to the following orthologs - mouse 91%, rat 86%.
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis, suggesting that Rho-related GTPases help coordinate motor skills and balance. Alternatively spliced transcript variants that encode different isoforms have been reported for this gene.
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Protein Aliases: Active breakpoint cluster region-related protein; MDB
Gene Aliases: ABR; MDB
UniProt ID: (Human) Q12979
Entrez Gene ID: (Human) 29