Invitrogen

ACACB Polyclonal Antibody

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ACACB Antibody in Western Blot (WB) — Western blot analysis of ACACB in MCF7 cell lysate. Samples were incubated with ACACB polyclonal antibody (Product # PA5-102963).

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1000-1:3000

-

Product Specifications

Species

Human, Mouse

Expression System

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ACACB, corresponding to a region within N-terminal amino acids.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

0.02% sodium azide

Storage conditions

-20°C

RRID

AB_2852337

Target Information

Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ACC-beta; Acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase beta; Biotin carboxylase

Gene Aliases: ACACB; ACC2; ACCB; AI597064; AW743042; HACC275

UniProt ID: (Human) O00763, (Mouse) E9Q4Z2

Entrez Gene ID: (Human) 32, (Mouse) 100705

Molecular Function: ligase

acetyl-CoA metabolic process fatty acid biosynthetic process biotin metabolic process carnitine shuttle negative regulation of gene expression positive regulation of lipid storage regulation of glucose metabolic process positive regulation of cellular metabolic process response to nutrient levels negative regulation of fatty acid beta-oxidation negative regulation of catalytic activity protein homotetramerization positive regulation of heart growth energy homeostasis malonyl-CoA biosynthetic process lipid metabolic process fatty acid metabolic process metabolic process response to organic cyclic compound negative regulation of fatty acid oxidation

Process(es)

acetyl-CoA carboxylase activity biotin carboxylase activity protein binding ATP binding metal ion binding nucleotide binding catalytic activity biotin binding ligase activity