Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACC-beta; Acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase beta; Biotin carboxylase
Gene Aliases: ACACB; ACC2; ACCB; AI597064; AW743042; HACC275
Molecular Function: ligase