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Abnova
ACACB Monoclonal Antibody (3E8)
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Product Details
H00000032-M02A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM, kappa
Class
Monoclonal
Type
Antibody
Clone
3E8
Immunogen
ACACB (NP_001084, 22 a.a. approximately 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: IWGKMTDSKP ITKSKSEANL IPSQEPFPAS DNSGETPQRN GEGHTLPKTP SQAEPASHKG PKDAGRRRNS LPPSHQKPPR NPLSSSDAAP SPELQANGT
Target Information
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage. May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACC-beta; Acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase beta; unnamed protein product
Gene Aliases: ACACB; ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta; HACC275
UniProt ID: (Human) O00763
Entrez Gene ID: (Human) 32
acetyl-CoA metabolic process
pentose-phosphate shunt
purine nucleotide metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
acyl-CoA metabolic process
response to nutrient
response to xenobiotic stimulus
positive regulation of lipid storage
regulation of glucose metabolic process
fatty acid oxidation
response to nutrient levels
negative regulation of fatty acid beta-oxidation
negative regulation of fatty acid oxidation
glucose import
lactic acid secretion
negative regulation of lipid catabolic process
protein homotetramerization
fatty acid homeostasis
positive regulation of heart growth
response to caloric restriction
tricarboxylic acid metabolic process
intracellular aspartate homeostasis
glutamate homeostasis
energy homeostasis
regulation of cardiac muscle hypertrophy in response to stress
malonyl-CoA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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