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Product Details
17526-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 10 publications 10 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:400 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Peptide |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.27 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
The size difference between the precursor and mature rat LCAD has been estimated to be 3 kDa on the basis of SDS-PAGE. Defects in ACADL are a cause of acyl-CoA dehydrogenase very long-chain deficiency (ACADVLD). This antibody is specific to ACADL.
Target Information
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acetyl-Coenzyme A dehydrogenase, long-chain; Acyl Coenzyme A dehydrogenase, long chain; acyl-Coenzyme A dehydrogenase, long chain; acyl-Coenzyme A dehydrogenase, long-chain; LCAD; LCAD long chain acyl-CoA dehydrogenase; long-chain acyl-CoA dehydrogenase; Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene Aliases: AA960361; ACAD4; ACADL; ACOADA; AU018452; C79855; LCAD
UniProt ID: (Human) P28330, (Mouse) Q8QZR6, (Rat) P15650
Entrez Gene ID: (Human) 33, (Mouse) 11363, (Rat) 25287
Molecular Function:
dehydrogenase
temperature homeostasis
fatty acid beta-oxidation
carnitine metabolic process, CoA-linked
fatty acid beta-oxidation using acyl-CoA dehydrogenase
carnitine catabolic process
long-chain fatty acid catabolic process
cellular lipid catabolic process
negative regulation of fatty acid biosynthetic process
negative regulation of fatty acid oxidation
protein homotetramerization
lipid homeostasis
oxidation-reduction process
regulation of cholesterol metabolic process
lipid metabolic process
fatty acid metabolic process
metabolic process
fatty-acyl-CoA binding
acyl-CoA dehydrogenase activity
long-chain-acyl-CoA dehydrogenase activity
electron carrier activity
palmitoyl-CoA oxidase activity
flavin adenine dinucleotide binding
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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