Peptide sequence: VLSQNRTENA QKAGHFDKEI VPVLVSTRKG LIEVKTDEFP RHGSNIEAMS
Sequence homology: Cow: 79%; Dog: 86%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 79%; Rat: 79%; Yeast: 82%
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.
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Protein Aliases: acetoacetyl Coenzyme A thiolase; Acetyl-CoA acetyltransferase, cytosolic; Acetyl-CoA transferase-like protein; AE1; BND3; Cytosolic acetoacetyl-CoA thiolase; DI; EMPB3; EPB3; RTA1A; SW; WD; WD1; WR
Gene Aliases: ACAT2; ACTL
UniProt ID: (Human) Q9BWD1
Entrez Gene ID: (Human) 39
Molecular Function: acyltransferase