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Proteintech
ACBD3 Polyclonal Antibody
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Product Details
14096-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACBD3 Fusion Protein Ag5228 (229-528 aa encoded by BC060792)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RRRIEEERL RLEQQKQQIM AALNSQTAVQ FQQYAAQQYP GNYEQQQILI RQLQEQHYQQ YMQQLYQVQL AQQQAALQKQ QEVVVAGSSL PTSSKVNATV PSNMMSVNGQ AKTHTDSSEK ELEPEAAEEA LENGPKESLP VIAAPSMWTR PQIKDFKEKI QQDADSVITV GRGEVVTVRV PTHEEGSYLF WEFATDNYDI GFGVYFEWTD SPNTAVSVHV SESSDDDEEE EENIGCEEKA KKNANRPLLD EIVPVYRRDC HEEVYAGSHQ YPGRGVYLLK FDNSYSLWRS KSVYYRVYYT R (229-528 aa encoded by BC060792)
Target Information
GOLPH1, also known as GCP60, was initially identified as a Golgi protein that can interact with the integral membrane protein giantin and is thought to be involved in the maintenance of the Golgi structure. GOLPH1 has also been shown to interact with other Golgi proteins such as Golgin-160, a Golgi protein that can be cleaved by caspases-2, -3, and -7, leading to the nuclear localization of Golgin-160. GOLPH1 interaction with the Golgin-160 fragments is stronger than that with the intact Golgin-160, with its interaction regulated by the oxidation state of Cys-463 within GOLPH1, suggesting that the nuclear localization of the caspase-cleaved Golgin-160 fragments is a highly coordinated event. GOLPH1 has also been found to interact with Numb, a cytosolic signaling protein that mediates asymetric cell division of neural progenitor cells to a daughter progenitor cell and a neuron, suggesting that Golgi fragmentation and reconstitution during the cell cycle differentially regulate Numb signaling through changes in GOLPH1 subcellular distribution and may couple cell fate with cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyl-CoA-binding domain-containing protein 3; acyl-Coenzyme A binding domain containing 3; DAP; DMT1-associated protein; GOCAP1; golgi complex associated protein 1, 60 kDa; golgi complex associated protein 1, 60kDa; Golgi complex-associated protein 1; Golgi phosphoprotein 1; Golgi resident protein GCP60; GOLPH1; neurotrophin receptor alike death domain protein; p75-like apoptosis-inducing death domain protein; PAP7; PBR associated protein; PBR associated protein; PBR- and PKA-associated protein 7; Peripheral benzodiazepine receptor-associated protein PAP7; peripherial benzodiazepine receptor associated protein; PKA (RIalpha)-associated protein; unnamed protein product
Gene Aliases: 60kDa; 8430407O11Rik; ACBD3; D1Ertd10e; GCP60; GOCAP1; GOLPH1; PAP7
UniProt ID: (Human) Q9H3P7, (Rat) Q7TNY6, (Mouse) Q8BMP6
Entrez Gene ID: (Human) 64746, (Rat) 289312, (Mouse) 170760
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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