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Invitrogen
ACE2 Polyclonal Antibody
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FIGURE: 1 / 18
ACE2 Antibody (PA5-47488) in IHC (F)
Immunohistochemical analysis of ACE2 in perfusion fixed frozen sections of mouse kidney. Samples were incubated in ACE2 polyclonal antibody (Product # PA5-47488) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and... View More
Product Details
PA5-47488
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant mouse ACE-2 Gln18-Thr740
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blots, approximately 40% cross-reactivity with recombinant human ACE-2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ACE 2; ACE-related carboxypeptidase; ACE2; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; anigotensin-converting enzyme-related carboxypeptidase; Metalloprotease MPROT15; peptidyl-dipeptidase A; renal angiotensin-converting enzyme 2; sACE2; N-terminally-truncated natural isoform; unnamed protein product; zinc metalloprotease
Gene Aliases: 2010305L05Rik; ACE2; ACEH; UNQ868/PRO1885
UniProt ID: (Human) Q9BYF1, (Rat) Q5EGZ1, (Mouse) Q8R0I0
Entrez Gene ID: (Human) 59272, (Rat) 302668, (Mouse) 70008
virus receptor activity
endopeptidase activity
carboxypeptidase activity
metallocarboxypeptidase activity
protein binding
peptidase activity
metallopeptidase activity
peptidyl-dipeptidase activity
zinc ion binding
hydrolase activity
identical protein binding
metal ion binding
transporter activator activity
glycoprotein binding
metalloprotease
negative regulation of transcription from RNA polymerase II promoter
regulation of cytokine production
angiotensin maturation
angiotensin-mediated drinking behavior
regulation of systemic arterial blood pressure by renin-angiotensin
proteolysis
tryptophan transport
viral life cycle
receptor-mediated endocytosis of virus by host cell
viral translation
regulation of vasoconstriction
regulation of cell proliferation
ceramide biosynthetic process
viral entry into host cell
receptor-mediated virion attachment to host cell
negative regulation of smooth muscle cell proliferation
regulation of inflammatory response
positive regulation of amino acid transport
maternal process involved in female pregnancy
positive regulation of cardiac muscle contraction
membrane fusion
negative regulation of ERK1 and ERK2 cascade
regulation of blood vessel diameter
entry receptor-mediated virion attachment to host cell
positive regulation of gap junction assembly
regulation of cardiac conduction
positive regulation of L-proline import across plasma membrane
positive regulation of reactive oxygen species metabolic process
response to virus
receptor biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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