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Invitrogen
ACER3 Polyclonal Antibody
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Product Details
PA5-101416
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ACER3(Accession Q9NUN7), corresponding to amino acid residues T177-G227.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PHCA.
Target Information
ACER3 is a protein coding gene. Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alkaline CDase 3; Alkaline ceramidase 3; Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; AlkCDase 3; aPHC; phytoceramidase, alkaline; unnamed protein product
Gene Aliases: 1110057L18Rik; 5430429L08Rik; ACER3; APHC; AV015045; PHCA; PLDECO; RGD1561254
UniProt ID: (Human) Q9NUN7, (Mouse) Q9D099
Entrez Gene ID: (Human) 55331, (Mouse) 66190, (Rat) 499210
calcium ion binding
zinc ion binding
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
ceramidase activity
metal ion binding
histone deacetylase activity
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
N-acetylgalactosamine-6-phosphate deacetylase activity
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
phytoceramidase activity
molecular_function
ceramide metabolic process
positive regulation of cell proliferation
sphingosine biosynthetic process
phytosphingosine biosynthetic process
lipid metabolic process
sphingolipid metabolic process
inflammatory response
myelination
regulation of programmed cell death
ceramide catabolic process
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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