Acyl-CoA thioesterases (ACOTs) are a group of enzymes that catalyze the hydrolysis of acyl-CoA to form coenzyme A (CoA) and a free fatty acid. Through their catalytic activity, ACOTs are able to regulate the level of fatty acids and acyl-CoAs within the cell. ACOT1 (acyl-CoA thioesterase 1, also known as CTE1) and ACOT2 (acyl-CoA thioesterase 2, also known as PTE2) are members of the ACOT family and exhibit different cellular localization, with ACOT1 existing as a monomer in the cytoplasm and ACOT2 localized primarily to mitochondria. Characteristic of most ACOT proteins, ACOT1 and ACOT2 catalyze the conversion of Palmitoyl-CoA and water to free CoA and palmitate, a reaction that is important for the regulation of intercellular fatty acid levels. ACOT2 is expressed as multiple alternatively spliced isoforms and, like ACOT1, is encoded by a gene which maps to human chromosome 14.
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Protein Aliases: Acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterase 2; Acyl-coenzyme A thioester hydrolase 2a; Acyl-coenzyme A thioesterase 2, mitochondrial; ARTISt/p43; CTE Ia; CTE-Ia; Long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; MTE-I; peroxisomal long-chain acyl-coA thioesterase 2; Very-long-chain acyl-CoA thioesterase; ZAP128
Gene Aliases: AA571646; ACOT2; CTE-IA; CTE1A; MTE-I; MTE1; PTE2; PTE2A; ZAP128