PA5-27973 targets ACOT8 in WB applications and shows reactivity with Human samples.
The PA5-27973 immunogen is recombinant fragment corresponding to a region within amino acids 42 and 304 of Human ACOT8.
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The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.
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Protein Aliases: Acyl-CoA thioesterase 8; Acyl-coenzyme A thioesterase 8; choloyl-CoA hydrolase; Choloyl-coenzyme A thioesterase; hACTE-III; HIV-Nef associated acyl-CoA thioesterase; HIV-Nef-associated acyl-CoA thioesterase; HNAACTE; hTE; long-chain fatty-acyl-CoA hydrolase; Nef (lentivirus myristoylated factor) associated protein 1; palmitoyl-CoA hydrolase; peroxisomal acyl-CoA thioesterase 1; peroxisomal acyl-coenzyme A thioe; Peroxisomal acyl-coenzyme A thioester hydrolase 1; Peroxisomal long-chain acyl-CoA thioesterase 1; PTE-1; PTE-2; PTE1; PTE2; Thioesterase II; thioesterase III
Gene Aliases: ACOT8; ACTEIII; hACTE-III; HNAACTE; hTE; NAP1; PTE-1; PTE-2; PTE1; PTE2
UniProt ID: (Human) O14734
Entrez Gene ID: (Human) 10005