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Alomone Labs, LTD
CRLR/CALCRL (extracellular) Polyclonal Antibody
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FIGURE: 1 / 6
CRLR/CALCRL (extracellular) Antibody (ACR-060-200UL) in IHC (F)
Expression of Calcitonin Receptor-Like Receptor in mouse brain stem - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-CRLR/CALCRL (extracellular) (extracellular) Antibody (#ACR-060), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. CRLR staining (green) in the Raphe Magnus region is detected in (green) in neurons (arrows). B. Pre-incubation of the Antibody with ... View More
Product Details
ACR-060-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide CNVNTHEKVKTALN, corresponding to amino acid residues 127 - 140 of human Calcitonin Receptor-Like Receptor, Extracellular, N-terminus.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
CRLR is a receptor for calcitonin gene-related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-cell/lung/testis, bome marrow, embryo, lung and synovium libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcitonin gene-related peptide type 1 receptor; calcitonin receptor-like; Calcitonin receptor-like receptor; CGRP receptor; CGRP type 1 receptor; Cgrp1 receptor; CRLR; G-protein coupled receptor; unnamed protein product
Gene Aliases: AV071593; CALCRL; CGRPR; CLR; CRLR; LMPHM8; RATCRLR; RNCLR
UniProt ID: (Human) Q16602, (Rat) Q63118, (Mouse) Q9R1W5
Entrez Gene ID: (Human) 10203, (Rat) 25029, (Mouse) 54598
adrenomedullin receptor activity
calcitonin gene-related peptide receptor activity
transmembrane signaling receptor activity
G-protein coupled receptor activity
calcitonin receptor activity
protein binding
adrenomedullin binding
protein transporter activity
signal transducer activity
transmembrane signal receptor
angiogenesis
calcium ion transport
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
heart development
cell proliferation
positive regulation of cell proliferation
protein transport
receptor internalization
smooth muscle cell proliferation
cellular response to sucrose stimulus
positive regulation of vascular smooth muscle cell proliferation
calcitonin gene-related peptide receptor signaling pathway
adrenomedullin receptor signaling pathway
vascular associated smooth muscle cell proliferation
cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
negative regulation of smooth muscle contraction
positive regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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