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Invitrogen
ACSL3 Polyclonal Antibody
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FIGURE: 1 / 5
ACSL3 Antibody (PA5-88208) in IHC (P)
Immunohistochemistry analysis of ACSL3 in paraffin-embedded human mammary cancer. Samples were incubated with ACSL3 Polyclonal antibody (Product # PA5-88208) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-88208
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
1.53 mg/mL
Amount
153 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HeLa, Mouse kidney; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion outer membrane, Peroxisome membrane, Single-pass type III membrane protein
Immunogen sequence: CEMENEVLKV LSEAAISASL E
Target Information
An initial reaction in fatty acid metabolism in eukaryotic cells is activation of fatty acids catalyzed by acyl-CoA synthetase. FACL3 (fatty acid CoA ligase, long-chain 3) is identified as member of the acyl-CoA synthetase (ACS) family by PCR of rat brain cDNAs using primers based on the conserved region of the ACS protein. The 720-amino acid rat protein preferentially utilizes myristate, laurate, arachidonate, and eicosapentaenoate, and is expressed primarily in brain. The predicted 720-amino acid FACL3 human protein is 92% identical to that of rat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arachidonate--CoA ligase; Arachidonate--CoA ligase Acsl3; Brain acyl-CoA synthetase II; Fatty acid CoA ligase Acsl3; fatty acid Coenzyme A ligase, long chain 3; fatty-acid-Coenzyme A ligase, long-chain 3; LACS 3; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 3; Long-chain-fatty-acid--CoA ligase 3; Medium-chain acyl-CoA ligase Acsl3; predicted protein of HQ2194; unnamed protein product
Gene Aliases: 2610510B12Rik; ACS3; ACSL3; C85929; FACL3; LACS 3; LACS3; PRO2194
UniProt ID: (Human) O95573, (Rat) Q63151, (Mouse) Q9CZW4
Entrez Gene ID: (Human) 2181, (Rat) 114024, (Mouse) 74205
nucleotide binding
long-chain fatty acid-CoA ligase activity
protein binding
ATP binding
ligase activity
protein kinase binding
protein domain specific binding
medium-chain fatty acid-CoA ligase activity
arachidonate-CoA ligase activity
palmitoyl-CoA ligase activity
fatty acid-CoA ligase activity
acetate-CoA ligase activity
catalytic activity
ligase
long-chain fatty acid metabolic process
lipid metabolic process
fatty acid metabolic process
neuron differentiation
very-low-density lipoprotein particle assembly
long-chain fatty-acyl-CoA metabolic process
long-chain fatty-acyl-CoA biosynthetic process
positive regulation of Golgi to plasma membrane protein transport
long-chain fatty acid import
positive regulation of secretion
positive regulation of phosphatidylcholine biosynthetic process
fatty acid biosynthetic process
brain development
response to nutrient
metabolic process
response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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