This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-27137 targets FACL4 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-27137 immunogen is synthetic peptide corresponding to a region within amino acids 649 and 711 of Human FACL4.
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The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.
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Protein Aliases: ACS4; acyl-CoA synthetase 4; FACL4; fatty acid Coenzyme A ligase, long chain 4; fatty acid-Coenzyme A ligase long chain 4; fatty acid-Coenzyme A ligase, long chain 4; fatty-acid-Coenzyme A ligase; fatty-acid-Coenzyme A ligase, long-chain 4; LACS 4; LACS4; lignoceroyl-CoA synthase; long-chain 4; Long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; Long-chain-fatty-acid--CoA ligase 4; mACS4; MRX63; MRX68
Gene Aliases: 9430020A05Rik; ACS4; ACSL4; AU018108; FACL4; LACS4; MRX63; MRX68
Molecular Function: ligase