The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.
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Protein Aliases: acyl-CoA synthetase 4; Arachidonate--CoA ligase; fatty-acid-Coenzyme A ligase, long-chain 4; L MRX63; LACS 4; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; Long-chain-fatty-acid--CoA ligase 4
Gene Aliases: ACS4; ACSL4; FACL4; LACS4; MRX63; MRX68
UniProt ID: (Human) O60488
Entrez Gene ID: (Human) 2182
Molecular Function: ligase