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Invitrogen
ACSL6 Polyclonal Antibody
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Product Details
PA5-101652
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ACSL6(Accession Q9UKU0), corresponding to amino acid residues N498-G548.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ACSL6.
Target Information
FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t(5;12)(q31;p13) that involves ETV6 and ACSL6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACSL6 isoform d; ACSL6 isoform e; Arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 6; fatty-acid-Coenzyme A ligase, long-chain 6; L LACS5; LACS 6; long fatty acyl-CoA synthetase 2; Long-chain acyl-CoA synthetase 6; Long-chain-fatty-acid--CoA ligase 6; Long-chain-fatty-acid--CoA ligase, brain isozyme; unnamed protein product
Gene Aliases: A330035H04Rik; ACS2; ACSL6; AW050338; FACL6; KIAA0837; LACS; LACS 6; LACS2; LACS5; Lacsl; mKIAA0837
UniProt ID: (Human) Q9UKU0, (Mouse) Q91WC3, (Rat) P33124
Entrez Gene ID: (Human) 23305, (Mouse) 216739, (Rat) 117243
very long-chain fatty acid metabolic process
long-chain fatty acid metabolic process
lipid metabolic process
fatty acid metabolic process
acyl-CoA metabolic process
neuroblast proliferation
long-chain fatty-acyl-CoA biosynthetic process
triglyceride metabolic process
metabolic process
phospholipid biosynthetic process
positive regulation of plasma membrane long-chain fatty acid transport
positive regulation of triglyceride biosynthetic process
positive regulation of neuron projection development
fatty acid transport
response to hypoxia
response to nutrient
response to gravity
cellular response to insulin stimulus
response to steroid hormone
neuron development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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