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Proteintech
ACTL6A Polyclonal Antibody
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Product Details
10341-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACTL6A Fusion Protein Ag0323 (21-286 aa encoded by BC001391)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YTVRAGYAG EDCPKVDFPT AIGMVVERDD GSTLMEIDGD KGKQGGPTYY IDTNALRVPR ENMEAISPLK NGMVEDWDSF QAILDHTYKM HVKSEASLHP VLMSEAPWNT RAKREKLTEL MFEHYNIPAF FLCKTAVLTA FANGRSTGLI LDSGATHTTA IPVHDGYVLQ QGIVKSPLAG DFITMQCREL FQEMNIELVP PYMIASKEAV REGSPANWKR KEKLPQVTRS WHNYMCNCVI QDFQASVLQV SDSTYDEQVA AQMPTVH (21-286 aa encoded by BC001391)
Target Information
BAF53A is a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 53 kDa BRG1-associated factor A; actin-like 6; actin-like 6B; Actin-like protein 6A; actin-related protein 4; Actin-related protein Baf53a; ACTL6B; ArpNbeta; BAF complex 53 kDa subunit; BAF53; BAF53A; BAF53B; BRG1-associated factor 53A; BRG1/brm-associated factor 53A; hArpN alpha; hArpN beta; INO80 complex subunit K; MGC5382; MGC5382 Arp4; unnamed protein product
Gene Aliases: 2810432C06Rik; ACTL6; ACTL6A; AI851094; ARP4; ARPN-BETA; BAF53; BAF53A; C79802; INO80K; RGD1307747; SMARCN1
UniProt ID: (Human) O96019, (Mouse) Q9Z2N8
Entrez Gene ID: (Human) 86, (Mouse) 56456, (Rat) 361925
chromatin binding
transcription coactivator activity
protein binding
nucleosomal DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
molecular_function
actin and actin related protein
actin or actin-binding cytoskeletal protein
cytoskeletal protein
telomere maintenance
blastocyst formation
neural retina development
regulation of DNA replication
DNA repair
regulation of DNA repair
DNA recombination
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
signal transduction
nervous system development
positive regulation of cell proliferation
spinal cord development
regulation of mitotic metaphase/anaphase transition
regulation of chromosome organization
regulation of apoptotic process
positive regulation of T cell differentiation
negative regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
positive regulation of DNA repair
positive regulation of transcription, DNA-templated
regulation of embryonic development
system development
regulation of cell cycle
regulation of DNA strand elongation
regulation of G0 to G1 transition
positive regulation of stem cell population maintenance
positive regulation of telomere maintenance in response to DNA damage
positive regulation of double-strand break repair via homologous recombination
regulation of G1/S transition of mitotic cell cycle
regulation of double-strand break repair
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
transcription, DNA-templated
chromatin modification
regulation of growth
ATP-dependent chromatin remodeling
histone H4 acetylation
histone H2A acetylation
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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