Proteintech

ACVR1 Polyclonal Antibody

View all (17) ACVR1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
ACVR1 Polyclonal Antibody

Product Details

11108-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ACVR1 fusion protein Ag1556
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: LLECVGKGRY GEVWRGSWQG ENVAVKIFSS RDEKSWFRET ELYNTVMLRH ENILGFIASD MTSRHSSTQL WLITHYHEMG SLYDYLQLTT LDTVSCLRIV LSIASGLAHL HIEIFGTQGK PAIAHRDLKS KNILVKKNGQ CCIADLGLAV MHSQSTNQLD VGNNPRVGTK RYMAPEVLDE TIQVDCFDSY KRVDIWAFGL VLWEVARRMV SNGIVEDYKP PFYDVVPNDP SFEDMRKVVC VDQQRPNIPN RWFSDPTLTS LAKLMKECWY QNPSARLTAL RIKKTLTKID NSLDKLKTDC

Target Information

Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I

View more View less

Gene Aliases: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI

View more View less

UniProt ID: (Human) Q04771, (Rat) P80201, (Mouse) Q91VF1

View more View less

Entrez Gene ID: (Human) 90, (Rat) 79558, (Mouse) 11477

View more View less

Function(s)
protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta receptor activity, type I protein binding ATP binding activin receptor activity, type I peptide hormone binding protein homodimerization activity SMAD binding metal ion binding activin binding transforming growth factor beta binding growth factor binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
G1/S transition of mitotic cell cycle patterning of blood vessels in utero embryonic development gastrulation with mouth forming second mesoderm formation neural crest cell migration acute inflammatory response embryonic heart tube morphogenesis outflow tract septum morphogenesis atrioventricular valve morphogenesis mitral valve morphogenesis endocardial cushion morphogenesis endocardial cushion fusion atrial septum primum morphogenesis protein phosphorylation transforming growth factor beta receptor signaling pathway germ cell development determination of left/right symmetry negative regulation of signal transduction positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation regulation of ossification positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway negative regulation of activin receptor signaling pathway positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation pharyngeal system development pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis cardiac muscle cell fate commitment BMP signaling pathway involved in heart development endocardial cushion cell fate commitment cellular response to glucocorticoid stimulus cellular response to BMP stimulus positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of determination of dorsal identity negative regulation of extrinsic apoptotic signaling pathway urogenital system development gastrulation mesoderm development heart development regulation of skeletal muscle tissue development transmembrane receptor protein serine/threonine kinase signaling pathway embryo development phosphorylation intracellular signal transduction
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support