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Invitrogen

ACVR1 Polyclonal Antibody

View all (11) ACVR1 antibodies
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Product Details

Applications
Tested Dilution
Publications
Western Blot (WB)
3-5 µg/mL
-
Product Specifications
Species
Human, Mouse, Rat
Expression System
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues 475-525 of human ACVR1.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS with 0.2% gelatin
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2305086

Product Specific Information

By Western blot, this antibody detects a ~54 kDa band representing Activin Receptor Type IA.

Additional non-specific bands at ~14 and 27 kDa may also be detected in human kidney samples.

Suggested positive control: human kidney protein or tissue.

Target Information

The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I

Gene Aliases: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI

UniProt ID: (Human) Q04771, (Rat) P80201, (Mouse) P37172

Entrez Gene ID: (Human) 90, (Rat) 79558, (Mouse) 11477

Molecular Function: TGF-beta receptor cytokine receptor kinase protein kinase protein kinase receptor receptor serine/threonine protein kinase receptor transferase

Function(s)
G1/S transition of mitotic cell cycle patterning of blood vessels in utero embryonic development gastrulation with mouth forming second mesoderm formation neural crest cell migration acute inflammatory response embryonic heart tube morphogenesis outflow tract septum morphogenesis atrioventricular valve morphogenesis mitral valve morphogenesis endocardial cushion morphogenesis endocardial cushion fusion atrial septum primum morphogenesis protein phosphorylation transforming growth factor beta receptor signaling pathway germ cell development determination of left/right symmetry negative regulation of signal transduction positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation regulation of ossification positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway negative regulation of activin receptor signaling pathway positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation pharyngeal system development pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis cardiac muscle cell fate commitment BMP signaling pathway involved in heart development endocardial cushion cell fate commitment cellular response to glucocorticoid stimulus cellular response to BMP stimulus positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of determination of dorsal identity negative regulation of extrinsic apoptotic signaling pathway urogenital system development gastrulation mesoderm development heart development regulation of skeletal muscle tissue development transmembrane receptor protein serine/threonine kinase signaling pathway embryo development phosphorylation intracellular signal transduction
Process(es)
protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta receptor activity, type I protein binding ATP binding activin receptor activity, type I peptide hormone binding protein homodimerization activity SMAD binding metal ion binding activin binding transforming growth factor beta binding growth factor binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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