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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
3-5 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide corresponding to residues 475-525 of human ACVR1. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Protein G |
Storage buffer |
PBS with 0.2% gelatin |
Contains |
0.05% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2305086 |
By Western blot, this antibody detects a ~54 kDa band representing Activin Receptor Type IA.
Additional non-specific bands at ~14 and 27 kDa may also be detected in human kidney samples.
Suggested positive control: human kidney protein or tissue.
The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I
Gene Aliases: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI
UniProt ID: (Human) Q04771, (Rat) P80201, (Mouse) P37172
Entrez Gene ID: (Human) 90, (Rat) 79558, (Mouse) 11477
Molecular Function:
serine/threonine protein kinase receptor
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