PA5-28662 targets Activin A receptor type I in WB applications and shows reactivity with Human and Rat samples.
The PA5-28662 immunogen is recombinant fragment corresponding to a region within amino acids 214 and 509 of Human Activin A receptor type I.
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Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
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Protein Aliases: activin A receptor; activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ACTRI; ACVR1A; ACVRLK2; ALK-2; ALK2; ALK2-B; FOP; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; TSRI; type II-like kinase 2
Gene Aliases: ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI