Keep as concentrated solution.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activin A receptor; activin A receptor type I; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; activin receptor type I antibody; Activin receptor type-1; activin receptor type-1 antibody; Activin receptor-like kinase 2; activin receptor-like kinase 2 antibody; ACTR-I; ACTRI antibody; ACVR1 antibody; ACVR1A antibody; ACVRLK2 antibody; ALK-2; ALK2 antibody; FOP antibody; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase antibody; Serine/threonine-protein kinase receptor R1; serine/threonine-protein kinase receptor R1 antibody; SKR1; SKR1 antibody; TGF-B superfamily receptor type I; TGF-B superfamily receptor type I antibody; TSK-7L; TSR-I; TSRI antibody; type I antibody; type II-like kinase 2 antibody
Gene Aliases: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI