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Invitrogen
ACVR1B Polyclonal Antibody
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Product Details
PA5-20596
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide near the carboxy terminus of the human ACVR1B.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human kidney tissue lysate.
PA5-20596 can be used with blocking peptide PEP-0716.
Target Information
ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor, type IB; activin A receptor, type II-like kinase 4; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR-IB; ACTRI; ACVR1A; ACVRLK2; ALK-4; ALK2; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI; unnamed protein product
Gene Aliases: 6820432J04; ActR-IB; ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2
UniProt ID: (Human) P36896, (Mouse) Q61271
Entrez Gene ID: (Human) 91, (Mouse) 11479
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
activin receptor activity, type I
transferase activity
activin-activated receptor activity
growth factor binding
ubiquitin protein ligase binding
inhibin binding
SMAD binding
metal ion binding
activin binding
I-SMAD binding
receptor signaling protein serine/threonine kinase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
G1/S transition of mitotic cell cycle
in utero embryonic development
hair follicle development
regulation of transcription, DNA-templated
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
nervous system development
regulation of signal transduction
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
peptidyl-threonine phosphorylation
negative regulation of ossification
negative regulation of cell growth
regulation of cell migration
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
nodal signaling pathway
negative regulation of cell differentiation
positive regulation of erythrocyte differentiation
protein autophosphorylation
regulation of multicellular organismal process
cellular response to growth factor stimulus
extrinsic apoptotic signaling pathway
positive regulation of trophoblast cell migration
protein phosphorylation
cell surface receptor signaling pathway
mesoderm development
embryo development
positive regulation of pathway-restricted SMAD protein phosphorylation
phosphorylation
signal transduction by protein phosphorylation
intracellular signal transduction
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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