|Western Blot (WB)||1 ug/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 14 amino acid peptide near the carboxy terminus of the human ACVR1B.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is human kidney tissue lysate.
PA5-20596 can be used with blocking peptide PEP-0716.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activin A receptor type IB; activin A receptor, type IB; activin A receptor, type II-like kinase 2; activin A receptor, type II-like kinase 4; activin receptor type I; Activin receptor type IB; activin receptor type-1; Activin receptor type-1B; activin receptor-like kinase 2; Activin receptor-like kinase 4; ACTR-IB; ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI; ALK-4; hydroxyalkyl-protein kinase; serine/threonine-protein kinase receptor R1; Serine/threonine-protein kinase receptor R2; SKR2
Gene Aliases: 6820432J04; ActR-IB; ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.