PA5-27904 targets Activin A Receptor Type IC in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27904 immunogen is recombinant fragment corresponding to a region within amino acids 19 and 426 of Human Activin A Receptor Type IC.
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ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).
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Protein Aliases: activin A receptor type IC; activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACVR1C; ACVRLK7; ALK-7; ALK7
Gene Aliases: ACVR1C; ACVRLK7; ALK7
UniProt ID: (Human) Q8NER5
Entrez Gene ID: (Human) 130399