Invitrogen

ACVR2A Polyclonal Antibody

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ACVR2A Polyclonal Antibody

Product Details

PA5-114823

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ACVR2A(Accession P27037), corresponding to amino acid residues V284-L334.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899459

Product Specific Information

Antibody detects endogenous levels of total ACVR2A.

Target Information

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type IIA; activin A receptor, type IIA; activin receptor IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA; type II activin receptor

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Gene Aliases: ACTRII; ActrIIa; ACVR2; ACVR2A; rActR-II; TactrII

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UniProt ID: (Human) P27037, (Rat) P38444, (Mouse) P27038

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Entrez Gene ID: (Human) 92, (Rat) 29263, (Mouse) 11480

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Function(s)
protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding coreceptor activity activin-activated receptor activity growth factor binding PDZ domain binding inhibin binding protein self-association metal ion binding activin binding BMP receptor activity transforming growth factor beta-activated receptor activity activin receptor activity, type II nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
gastrulation with mouth forming second positive regulation of protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway spermatogenesis determination of left/right symmetry mesoderm development anterior/posterior pattern specification positive regulation of pathway-restricted SMAD protein phosphorylation signal transduction by protein phosphorylation positive regulation of bone mineralization BMP signaling pathway regulation of BMP signaling pathway activin receptor signaling pathway positive regulation of activin receptor signaling pathway sperm ejaculation penile erection positive regulation of erythrocyte differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system development regulation of nitric-oxide synthase activity Sertoli cell proliferation cellular response to BMP stimulus protein phosphorylation male gonad development regulation of signal transduction response to organic substance positive regulation of follicle-stimulating hormone secretion phosphorylation
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