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ACVR2A Polyclonal Antibody

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ACVR2A Polyclonal Antibody

Product Details

PA5-95374

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human ACVR2A recombinant protein (Position: Q421-L513).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807177

Product Specific Information

Human ACVR2A shares 100% and 98.9% amino acid (aa) sequence identity with mouse and rat ACVR2A, respectively.

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat kidney tissue, HELA whole cell. IHC: human intestinal cancer tissue. ICC/IF: NRK cell. Flow: HEPA1-6 cell, RH35 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor, type IIA; activin receptor IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA; type II activin receptor; unnamed protein product

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Gene Aliases: ACTRII; ActrIIa; ACVR2; ACVR2A; rActR-II; TactrII

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UniProt ID: (Human) P27037, (Rat) P38444, (Mouse) P27038

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Entrez Gene ID: (Human) 92, (Rat) 29263, (Mouse) 11480

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein binding ATP binding coreceptor activity kinase activity activin receptor activity, type I activin receptor activity, type II transferase activity activin-activated receptor activity growth factor binding PDZ domain binding inhibin binding identical protein binding metal ion binding activin binding BMP receptor activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity protein self-association transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
osteoblast differentiation gastrulation with mouth forming second positive regulation of protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway spermatogenesis determination of left/right symmetry pattern specification process mesoderm development male gonad development anterior/posterior pattern specification regulation of signal transduction negative regulation of ossification positive regulation of bone mineralization BMP signaling pathway developmental process activin receptor signaling pathway positive regulation of activin receptor signaling pathway odontogenesis of dentin-containing tooth sperm ejaculation penile erection regulation of nitric oxide biosynthetic process positive regulation of erythrocyte differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system development Sertoli cell proliferation positive regulation of SMAD protein import into nucleus cellular response to growth factor stimulus cellular response to BMP stimulus protein phosphorylation response to organic substance positive regulation of pathway-restricted SMAD protein phosphorylation signal transduction by protein phosphorylation regulation of BMP signaling pathway positive regulation of follicle-stimulating hormone secretion regulation of nitric-oxide synthase activity phosphorylation
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