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Product Details
PA5-14922
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 474-503 amino acids from the C-terminal region of human ACVRL1
Conjugate
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2222586
Target Information
Activins are a type of dimeric growth and differentiation factor that belong to the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins. They signal through a complex of receptor serine kinases, which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are transmembrane proteins that have a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, while type II receptors are required for binding ligands and for the expression of type I receptors. Upon ligand binding, type I and II receptors form a stable complex, resulting in the phosphorylation of type I receptors by type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type II-like 1; activin A receptor type IL; activin A receptor, type II-like kinase 1; Activin receptor-like kinase 1; ALK-1; Serine/threonine-protein kinase receptor R3; SKR3; TGF-B superfamily receptor type I; TSR-I
Gene Aliases: ACVRL1; ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I
UniProt ID: (Human) P37023
Entrez Gene ID: (Human) 94
Molecular Function:
serine/threonine protein kinase receptor
angiogenesis
in utero embryonic development
regulation of endothelial cell proliferation
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lymphangiogenesis
blood vessel maturation
blood vessel remodeling
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
endocardial cushion morphogenesis
regulation of DNA replication
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of cell adhesion
signal transduction
transforming growth factor beta receptor signaling pathway
blood circulation
regulation of blood pressure
negative regulation of cell proliferation
negative regulation of endothelial cell migration
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
signal transduction by protein phosphorylation
negative regulation of cell growth
negative regulation of cell migration
BMP signaling pathway
positive regulation of BMP signaling pathway
positive regulation of chondrocyte differentiation
activin receptor signaling pathway
wound healing, spreading of epidermal cells
dorsal aorta morphogenesis
regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
negative regulation of endothelial cell differentiation
positive regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein heterooligomerization
negative regulation of focal adhesion assembly
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
endothelial tube morphogenesis
retina vasculature development in camera-type eye
cellular response to transforming growth factor beta stimulus
cellular response to BMP stimulus
endocardial cushion to mesenchymal transition
negative regulation of DNA biosynthetic process
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
activin receptor activity, type I
protein kinase binding
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
BMP receptor activity
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