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Invitrogen
ACVRL1 Polyclonal Antibody
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Product Details
PA5-49803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from internal of human ACVL1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total ACVRL1 protein.
Target Information
Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2. Mutations in ACVRL1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type II-like 1; activin A receptor type IL; activin A receptor, type II-like kinase 1; Activin receptor like kinase 1; Activin receptor type-1-like; Activin receptor-like kinase 1; activin receptor-like kinase-1; ALK-1; Serine/threonine-protein kinase receptor R3; SKR3; TGF-B superfamily receptor type I; TSR-I
Gene Aliases: ACVRL1; ACVRLK1; AI115505; AI427544; ALK-1; ALK1; HHT; HHT2; ORW2; R-3; R3; SETHKIR; SKR3; TSR-I
UniProt ID: (Human) P37023, (Rat) P80203, (Mouse) Q61288
Entrez Gene ID: (Human) 94, (Rat) 25237, (Mouse) 11482
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
activin receptor activity, type I
protein kinase binding
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
BMP receptor activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
angiogenesis
in utero embryonic development
regulation of endothelial cell proliferation
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lymphangiogenesis
blood vessel maturation
blood vessel remodeling
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
endocardial cushion morphogenesis
regulation of DNA replication
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of cell adhesion
signal transduction
transforming growth factor beta receptor signaling pathway
blood circulation
regulation of blood pressure
negative regulation of cell proliferation
negative regulation of endothelial cell migration
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
signal transduction by protein phosphorylation
negative regulation of cell growth
negative regulation of cell migration
BMP signaling pathway
positive regulation of BMP signaling pathway
positive regulation of chondrocyte differentiation
activin receptor signaling pathway
wound healing, spreading of epidermal cells
dorsal aorta morphogenesis
regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
negative regulation of endothelial cell differentiation
positive regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein heterooligomerization
negative regulation of focal adhesion assembly
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
endothelial tube morphogenesis
retina vasculature development in camera-type eye
cellular response to transforming growth factor beta stimulus
cellular response to BMP stimulus
endocardial cushion to mesenchymal transition
negative regulation of DNA biosynthetic process
blood vessel morphogenesis
transmembrane receptor protein serine/threonine kinase signaling pathway
phosphorylation
intracellular signal transduction
endothelial cell activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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