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Invitrogen

ACVRL1 Polyclonal Antibody

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ACVRL1 Polyclonal Antibody

Product Details

PA5-86476

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 200-250 of Human ACVRL1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803254

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2. Mutations in ACVRL1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type II-like 1; activin A receptor type IL; activin A receptor, type II-like kinase 1; Activin receptor like kinase 1; Activin receptor type-1-like; Activin receptor-like kinase 1; activin receptor-like kinase-1; ALK-1; Serine/threonine-protein kinase receptor R3; serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; activin receptor-like kinase 1; SKR3; TGF-B superfamily receptor type I; TSR-I; unnamed protein product

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Gene Aliases: ACVRL1; ACVRLK1; AI115505; AI427544; ALK-1; ALK1; HHT; HHT2; ORW2; R-3; R3; SETHKIR; SKR3; TSR-I

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UniProt ID: (Human) P37023, (Rat) P80203, (Mouse) Q61288

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Entrez Gene ID: (Human) 94, (Rat) 25237, (Mouse) 11482

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I protein binding ATP binding kinase activity activin receptor activity, type I transferase activity protein kinase binding SMAD binding metal ion binding activin binding transforming growth factor beta binding BMP receptor activity receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
angiogenesis in utero embryonic development regulation of endothelial cell proliferation negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel maturation blood vessel remodeling blood vessel endothelial cell proliferation involved in sprouting angiogenesis endocardial cushion morphogenesis regulation of DNA replication regulation of transcription, DNA-templated negative regulation of cell adhesion signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway heart development blood circulation regulation of blood pressure negative regulation of cell proliferation dorsal/ventral pattern formation negative regulation of endothelial cell migration negative regulation of gene expression cell differentiation negative regulation of cell growth negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway positive regulation of epithelial cell differentiation positive regulation of chondrocyte differentiation activin receptor signaling pathway wound healing, spreading of epidermal cells dorsal aorta morphogenesis regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration endothelial cell differentiation positive regulation of cell differentiation negative regulation of endothelial cell differentiation positive regulation of endothelial cell differentiation positive regulation of Notch signaling pathway positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter blood vessel morphogenesis positive regulation of multicellular organismal process negative regulation of focal adhesion assembly positive regulation of SMAD protein import into nucleus epithelial tube morphogenesis lymphatic endothelial cell differentiation artery development venous blood vessel development endothelial tube morphogenesis retina vasculature development in camera-type eye cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus circulatory system development endocardial cushion to mesenchymal transition positive regulation of bicellular tight junction assembly regulation of multicellular organismal development protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation signal transduction by protein phosphorylation protein heterooligomerization negative regulation of DNA biosynthetic process phosphorylation intracellular signal transduction endothelial cell activation
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