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ADAM10 Polyclonal Antibody

View all (31) ADAM10 antibodies

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ADAM10 Polyclonal Antibody

Product Details

BS-3574R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human ADAM10, amino acids 501-600.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; ADAM; ADAM 10; ADAMs; disintegrin metalloprotease; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; metalloendopeptidases; RGD1566370; unnamed protein product

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Gene Aliases: 1700031C13Rik; AD10; AD18; CD156c; CDw156; HsT18717; kuz; kuzbanian; MADM; RAK

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UniProt ID: (Human) O14672, (Mouse) O35598, (Rat) Q10743

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Entrez Gene ID: (Human) 102, (Mouse) 11487, (Rat) 29650

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Function(s)
endopeptidase activity metalloendopeptidase activity integrin binding protein binding metallopeptidase activity protein homodimerization activity metallodipeptidase activity metalloendopeptidase activity involved in amyloid precursor protein catabolic process
Process(es)
in utero embryonic development proteolysis membrane protein ectodomain proteolysis negative regulation of cell adhesion Notch signaling pathway integrin-mediated signaling pathway cell-cell signaling positive regulation of cell proliferation regulation of Notch signaling pathway negative regulation of gene expression positive regulation of T cell chemotaxis protein processing extracellular matrix disassembly positive regulation of cell growth positive regulation of cell migration positive regulation of tumor necrosis factor production adherens junction organization response to tumor necrosis factor epidermal growth factor receptor ligand maturation monocyte activation negative regulation of amyloid precursor protein biosynthetic process amyloid precursor protein catabolic process pore complex assembly constitutive protein ectodomain proteolysis cochlea development regulation of neurotransmitter receptor localization to postsynaptic specialization membrane postsynapse organization regulation of postsynapse organization protein catabolic process at postsynapse signaling receptor ligand precursor processing regulation of vasculature development negative regulation of beta-amyloid formation positive regulation of tumor necrosis factor-mediated signaling pathway Notch receptor processing positive regulation of neuron projection development beta-amyloid formation positive regulation of apoptotic process regulation of dendritic spine morphogenesis spermatogenesis regulation of osteoclast differentiation response to antineoplastic agent
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