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Bioss
ADAM10 Polyclonal Antibody
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Product Details
BS-3574R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ADAM10, amino acids 501-600.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; ADAM; ADAM 10; ADAMs; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; metalloendopeptidases
Gene Aliases: 1700031C13Rik; AD10; AD18; ADAM10; CD156c; CDw156; HsT18717; KUZ; kuzbanian; MADM; RAK
UniProt ID: (Human) O14672, (Mouse) O35598, (Rat) Q10743
Entrez Gene ID: (Human) 102, (Mouse) 11487, (Rat) 29650
endopeptidase activity
metalloendopeptidase activity
receptor binding
integrin binding
protein binding
metallopeptidase activity
zinc ion binding
SH3 domain binding
protein kinase binding
protein homodimerization activity
peptidase activity
hydrolase activity
SH2 domain binding
metal ion binding
protease
in utero embryonic development
protein phosphorylation
membrane protein ectodomain proteolysis
negative regulation of cell adhesion
Notch signaling pathway
Notch receptor processing
integrin-mediated signaling pathway
cell-cell signaling
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
protein processing
extracellular matrix disassembly
positive regulation of cell growth
positive regulation of cell migration
response to tumor necrosis factor
monocyte activation
ephrin receptor signaling pathway
PMA-inducible membrane protein ectodomain proteolysis
constitutive protein ectodomain proteolysis
proteolysis
nucleocytoplasmic transport
regulation of osteoclast differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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