Search
Invitrogen
ADAM10 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-87899
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 218-433 of human ADAM10 (NP_0011011)
Conjugate
Form
Liquid
Concentration
0.62 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HT-1080, Raji, Jurkat, Mouse kidney, Mouse brain; Cellular Location: Cell membrane, Endomembrane system, Single-pass type I membrane protein
Immunogen sequence: EKNTCQLYIQ TDHLFFKYYG TREAVIAQIS SHVKAIDTIY QTTDFSGIRN ISFMVKRIRI NTTADEKDPT NPFRFPNIGV EKFLELNSEQ NHDDYCLAYV FTDRDFDDGV LGLAWVGAPS GSSGGICEKS KLYSDGKKKS LNTGIITVQN YGSHVPPKVS HITFAHEVGH NFGSPHDSGT ECTPGESKNL GQKENGNYIM YARATSGDKL NNNKFS
Target Information
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; ADAM; ADAM 10; ADAMs; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; metalloendopeptidases; unnamed protein product
Gene Aliases: 1700031C13Rik; AD10; AD18; ADAM10; CD156c; CDw156; HsT18717; KUZ; kuzbanian; MADM; RAK
UniProt ID: (Human) O14672, (Mouse) O35598
Entrez Gene ID: (Human) 102, (Mouse) 11487
endopeptidase activity
metalloendopeptidase activity
integrin binding
protein binding
peptidase activity
metallopeptidase activity
hydrolase activity
SH3 domain binding
protein kinase binding
protein homodimerization activity
metal ion binding
metallodipeptidase activity
metalloendopeptidase activity involved in amyloid precursor protein catabolic process
zinc ion binding
SH2 domain binding
protease
in utero embryonic development
proteolysis
membrane protein ectodomain proteolysis
negative regulation of cell adhesion
Notch signaling pathway
integrin-mediated signaling pathway
cell-cell signaling
positive regulation of cell proliferation
regulation of Notch signaling pathway
negative regulation of gene expression
positive regulation of T cell chemotaxis
protein processing
extracellular matrix disassembly
positive regulation of cell growth
positive regulation of cell migration
positive regulation of tumor necrosis factor production
adherens junction organization
response to tumor necrosis factor
epidermal growth factor receptor ligand maturation
monocyte activation
amyloid precursor protein catabolic process
pore complex assembly
constitutive protein ectodomain proteolysis
cochlea development
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
postsynapse organization
regulation of postsynapse organization
protein catabolic process at postsynapse
signaling receptor ligand precursor processing
regulation of vasculature development
positive regulation of tumor necrosis factor-mediated signaling pathway
protein phosphorylation
nucleocytoplasmic transport
Notch receptor processing
PMA-inducible membrane protein ectodomain proteolysis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support