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Invitrogen
ADAM15 Polyclonal Antibody
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FIGURE: 1 / 1
ADAM15 Antibody (PA5-47966) in IHC (P)
Immunohistochemical analysis of ADAM15 in immersion fixed paraffin-embedded sections of human prostate. Samples were incubated in ADAM15 polyclonal antibody (Product # PA5-47966) using a dilution of 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in epithelial... View More
Product Details
PA5-47966
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Sf 21-derived recombinant human ADAM15 Ectodomain Leu18-Ser693
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse (rm) ADAM15 is observed, and less than 1% cross-reactivity with rmADAM9, rmADAM10, recombinant human (rh) ADAM8, rhADAM9, rhADAM10, rhADAM12, rhADAM17 (TACE), rhADAM19, rhADAM22, rhADAM23, rhADAM32, and rhADAM33 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 15 (metargidin); ADAM; ADAM 15; ADAMs; Disintegrin and metalloproteinase domain-containing protein 15; MDC-15; metalloendopeptidases; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metargidin
Gene Aliases: ADAM15; MDC15
UniProt ID: (Human) Q13444
Entrez Gene ID: (Human) 8751
angiogenesis
negative regulation of cell-matrix adhesion
proteolysis
apoptotic process
cell-matrix adhesion
integrin-mediated signaling pathway
male gonad development
extracellular matrix disassembly
negative regulation of cell growth
negative regulation of cell migration
collagen catabolic process
tissue regeneration
innate immune response
cardiac epithelial to mesenchymal transition
protein kinase C signaling
negative regulation of receptor binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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