Invitrogen

ADAM17 Polyclonal Antibody

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ADAM17 Polyclonal Antibody

Product Details

PA1-31074

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

3.75 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence LQRQNRVDSKETEC, from the C Terminus.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1960914

Product Specific Information

Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX13535-PEP)..



Expected to cross-react with Chinese Hamster due to sequence homology.



Detects a band of approximately 125-130 kDa (predicted molecular weight: 95 or when glycosylated 130 kDa).

Target Information

ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane bound precusor of TNF-alpha to its mature soluble form. ADAM 17 is responsbile for the proteolytical release of soluble JAM3 from endothelial cells surface and the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein. It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: a disintegrin and metalloproteinase; ADAM; ADAM 17; ADAM metallopeptidase domain 18; ADAMs; CD156b; CD156b antigen; Disintegrin and metalloproteinase domain-containing protein 17; metalloendopeptidases; Snake venom-like protease; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme

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Gene Aliases: ADAM17; ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE

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UniProt ID: (Human) P78536

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Entrez Gene ID: (Human) 6868

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Function(s)
metalloendopeptidase activity Notch binding interleukin-6 receptor binding integrin binding protein binding metallopeptidase activity zinc ion binding SH3 domain binding PDZ domain binding protease
Process(es)
response to hypoxia positive regulation of protein phosphorylation neutrophil mediated immunity germinal center formation positive regulation of leukocyte chemotaxis proteolysis membrane protein ectodomain proteolysis cell adhesion epidermal growth factor receptor signaling pathway Notch signaling pathway Notch receptor processing positive regulation of cell proliferation positive regulation of T cell chemotaxis B cell differentiation positive regulation of cell growth positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway membrane protein intracellular domain proteolysis positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle response to lipopolysaccharide positive regulation of chemokine production regulation of mast cell apoptotic process T cell differentiation in thymus tumor necrosis factor-mediated signaling pathway cell adhesion mediated by integrin wound healing, spreading of epidermal cells epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway response to drug positive regulation of epidermal growth factor-activated receptor activity spleen development cell motility defense response to Gram-positive bacterium PMA-inducible membrane protein ectodomain proteolysis positive regulation of cellular component movement response to high density lipoprotein particle
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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