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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction.
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Protein Aliases: a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 19 (meltrin beta); ADAM; ADAM 19; ADAMs; Disintegrin and metalloproteinase domain-containing protein 19; MADDAM; Meltrin-beta; metalloendopeptidases; Metalloprotease and disintegrin dendritic antigen marker; metalloprotease-disintegrin meltrin beta
Gene Aliases: ADAM19; FKSG34; MADDAM; MLTNB
UniProt ID: (Human) Q9H013
Entrez Gene ID: (Human) 8728
Molecular Function: metalloprotease