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Invitrogen
ADAM8 Polyclonal Antibody
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FIGURE: 1 / 2
ADAM8 Antibody (PA5-98303) in ICC/IF
Immunofluorescent analysis of ADAM8 in MCF-7 cells using a ADAM8 polyclonal antibody (Product # PA5-98303) at a dilution of 1:133. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were counter-stained with DAPI.
Product Details
PA5-98303
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Disintegrin and metalloproteinase domain-containing protein 8 protein (677-824AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 8; ADAM; ADAM 8; ADAMs; CD156a; Cell surface antigen MS2; Disintegrin and metalloproteinase domain-containing protein 8; human leukocyte differentiation antigen; metalloendopeptidases; MGC134985; unnamed protein product
Gene Aliases: ADAM8; CD156; CD156a; MS2
UniProt ID: (Human) P78325
Entrez Gene ID: (Human) 101
metalloendopeptidase activity
serine-type endopeptidase activity
calcium ion binding
protein binding
peptidase activity
metallopeptidase activity
zinc ion binding
hydrolase activity
tumor necrosis factor receptor superfamily binding
immunoglobulin receptor binding
metal ion binding
cell adhesion molecule binding
cell morphogenesis
angiogenesis
leukocyte migration involved in inflammatory response
positive regulation of acute inflammatory response
positive regulation of cellular extravasation
proteolysis
inflammatory response
I-kappaB kinase/NF-kappaB signaling
positive regulation of epithelial to mesenchymal transition
positive regulation of protein processing
regulation of cell-cell adhesion
extracellular matrix disassembly
signal release
positive regulation of T cell differentiation in thymus
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of innate immune response
positive regulation of bone resorption
positive regulation of cell adhesion
lymphocyte chemotaxis
positive regulation of protein secretion
positive regulation of inflammatory response
positive regulation of membrane protein ectodomain proteolysis
positive regulation of protein kinase B signaling
positive regulation of thymocyte apoptotic process
cellular response to hypoxia
cell-cell adhesion
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
positive regulation of neutrophil extravasation
positive regulation of T cell migration
positive regulation of fibronectin-dependent thymocyte migration
positive regulation of eosinophil migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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