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Invitrogen
ADAMTS12 Polyclonal Antibody
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FIGURE: 1 / 2
ADAMTS12 Antibody (PA5-68084) in WB
The Journal of clinical investigation 2024 -
Rescue of ADAMTS12 KO by overexpression of catalytically active or inactive ADAMTS12. ( A ) Sequencing of ADAMTS12 expression plasmids with a WT active (Act) or a mutated inactive (Inact) catalytic domain. Seq, original ADAMTS12 sequence; Act, active catalytic domain; Inact, inactive catalytic domain. ( B ) Western blot for HA, tubulin, and GFP in ADAMTS12 -KO, active or inactive ADAMTS12-expressing PDGFRbe... View More
Product Details
PA5-68084
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human ADAMTS12.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This protein is a disintegrin and metalloproteinase with thrombospondin motifs-12 (ADAMTS12), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; ADAM; ADAM-TS 12; ADAM-TS12; ADAMs; ADAMTS-12; metalloendopeptidases; UNQ1918
Gene Aliases: ADAMTS12; PRO4389; UNQ1918/PRO4389
UniProt ID: (Human) A2RRN9
Entrez Gene ID: (Human) 81792
ossification
chondrocyte differentiation
proteoglycan metabolic process
proteolysis
cell-matrix adhesion
cell migration
proteoglycan catabolic process
extracellular matrix organization
collagen fibril organization
negative regulation of chondrocyte differentiation
ossification involved in bone maturation
regulation of inflammatory response
proteolysis involved in cellular protein catabolic process
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to BMP stimulus
regulation of endothelial tube morphogenesis
negative regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of cellular response to vascular endothelial growth factor stimulus
negative regulation of cellular response to hepatocyte growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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