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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues C H(592) S T N R L T L A V A W(603) of human ADAMTS15.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-1743 detects ADAMTS15 in human samples. In Western blot analysis of lysate from 293EBNA cells transfected with a partial ADAMTS15 sequence, this antibody detects an ~50 kDa protein representing ADAMTS15.
The PA1-1743 immunogen is a synthetic peptide corresponding to residues C H(592) S T N R L T L A V A W(603) of human ADAMTS15.
ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The immunizing peptide sequence is 100% conserved between human, mouse and rat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A disintegrin and metalloproteinase with thrombospondin motifs 15; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein; ADAM-TS 15; ADAM-TS15; ADAMTS-15; metalloprotease disintegrin 15 with thrombospondin domains