ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The immunizing peptide sequence is 100% conserved between human, mouse and rat.
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Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 15; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein; ADAM; ADAM-TS 15; ADAM-TS15; ADAMs; ADAMTS-15; metalloendopeptidases; metalloprotease disintegrin 15 with thrombospondin domains
Gene Aliases: ADAMTS15
UniProt ID: (Human) Q8TE58
Entrez Gene ID: (Human) 170689